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G protein-gated inwardly rectifying potassium channel (GIRK) plays a key role in regulating neurotransmission. GIRK is opened by the direct binding of the G protein βγgirk subunit (Gβγ),...

Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GIRK1, GIRK2, GIRK3, and GIRK4. The GIRK subunits come together to form GIRK ion channels.

G-protein-gated inwardly rectifying K + (GIRK) channels play a key role in maintaining resting membrane potential, cell excitability and inhibitory neurotransmission.

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